1.
Bioorg Med Chem Lett
; 30(1): 126662, 2020 01 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31784322
RESUMO
Starting from easy accessible pyrazoletetrahydropyran acetals, a series of new pyrazolone spirocyclohexadienone derivatives were synthesized and assayed for antitumor activity. Compound 10s was identified to possess good antitumor activity. It could induce MDA-MB-231 cancer cell apoptosis in a concentration dependent manner and arrest the cell cycle progression mainly at the G1 phase.